England wing Immanuel Feyi-Waboso is ruled out of the rest of the Nations Championship as his injury misfortune continues.
England ease pressure on Borthwick after big win over Australia
The 23-year-old injured his ankle in the first half of Sunday's 45-22 win over Australia in a "hip-drop" tackle by Angus Bell, for which the Wallabies prop received a yellow card.
England will also be without a handful of other key players for the match against Japan on Saturday, with Seb Atkinson, forward Ollie Chessum and full-back George Furbank all ruled out.
In a further blow, it has been confirmed experienced flanker Tom Curry will not feature this autumn after feeling discomfort in his hip.
Newcastle's uncapped flanker Max Hicks has been called into the 36-man squad, along with Harlequins' Jack Kenningham, while scrum-half Archie McParland, centre Max Ojomoh and wings Noah Calouri and Tobias Elliott are also included.
Source: BBC Sport